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type I interferons

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Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-134315
    8-Nitroguanosine

    		Nucleoside Antimetabolite/Analog Others
    8-Nitroguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    8-Nitroguanosine
  • HY-152610
    3′-C-Methylguanosine

    		Nucleoside Antimetabolite/Analog Others
    3′-C-Methylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    3′-C-Methylguanosine
  • HY-152517
    8-(Methylthio)guanosine

    		Nucleoside Antimetabolite/Analog Others
    8-(Methylthio)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    8-(Methylthio)guanosine
  • HY-154332
    8-(Phenylmethoxy)guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    8-(Phenylmethoxy)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    8-(Phenylmethoxy)guanosine
  • HY-152430
    8-Hydroxymethyl guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    8-Hydroxymethyl guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    8-Hydroxymethyl guanosine
  • HY-137406
    1,2'-O-Dimethylguanosine

    		Nucleoside Antimetabolite/Analog Others
    1,2'-O-Dimethylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    1,2'-O-Dimethylguanosine
  • HY-154506
    N2-Phenoxyacetylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-Phenoxyacetylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-Phenoxyacetylguanosine
  • HY-152673
    9-(β-D-Xylofuranosyl)guanine

    		Nucleoside Antimetabolite/Analog Cancer
    9-(β-D-Xylofuranosyl)guanine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    9-(β-D-Xylofuranosyl)guanine
  • HY-152652
    5’(R)-C-Methylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    5’(R)-C-Methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    5’(R)-C-Methylguanosine
  • HY-154111
    8-(N-Boc-aminomethyl)guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    8-(N-Boc-aminomethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    8-(N-Boc-aminomethyl)guanosine
  • HY-152742
    8-(N,N-Dimethylaminomethyl)guanosine

    		Nucleoside Antimetabolite/Analog Others
    8-(N,N-Dimethylaminomethyl)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    8-(N,N-Dimethylaminomethyl)guanosine
  • HY-152493
    3’-O-(2-Methoxyethyl)guanosine

    		Nucleoside Antimetabolite/Analog Others
    3’-O-(2-Methoxyethyl)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    3’-O-(2-Methoxyethyl)guanosine
  • HY-152991
    6-Deoxo-8-oxo-3’-deoxy-guanosine

    		Nucleoside Antimetabolite/Analog Others
    2′-Deoxy-N-(2-furanylmethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    6-Deoxo-8-oxo-3’-deoxy-guanosine
  • HY-154484
    3’-O-Me-G(iBu)-2’-phosphoramidite

    		Nucleoside Antimetabolite/Analog Cancer
    3’-O-Me-G(iBu)-2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    3’-O-Me-G(iBu)-2’-phosphoramidite
  • HY-154549
    3’-O-MOE-G(iBu)-2’-phosphoramidite

    		Nucleoside Antimetabolite/Analog Cancer
    3’-O-MOE-G(iBu)-2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    3’-O-MOE-G(iBu)-2’-phosphoramidite
  • HY-154336
    N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine
  • HY-152993
    2′-Deoxy-N-(2-furanylmethyl)guanosine

    		Nucleoside Antimetabolite/Analog Others
    2′-Deoxy-N-(2-furanylmethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    2′-Deoxy-N-(2-furanylmethyl)guanosine
  • HY-128139
    2'-C-Methylguanosine

    2'-C-beta-Methylguanosine

    		 Nucleoside Antimetabolite/Analog Others
    2'-C-Methylguanosine (2'-C-beta-Methylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    2'-C-Methylguanosine
  • HY-152992
    7-Cyano-7-deaza-2'-deoxy guanosine

    		Nucleoside Antimetabolite/Analog Others
    7-Cyano-7-deaza-2'-deoxy guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    7-Cyano-7-deaza-2'-deoxy guanosine
  • HY-152988
    N2-iso-Butyroyl-7'-O-DMT-morpholinoguanine

    		Nucleoside Antimetabolite/Analog Others
    N2-iso-Butyroyl-7'-O-DMT-morpholinoguanine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-iso-Butyroyl-7'-O-DMT-morpholinoguanine
  • HY-154547
    N2-iso-Butyroyl-3’-O-(methoxyethyl)guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-iso-Butyroyl-3’-O-(methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-iso-Butyroyl-3’-O-(methoxyethyl)guanosine
  • HY-154482
    N2-iso-Butyroyl-3’-O-methylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-iso-Butyroyl-3’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-iso-Butyroyl-3’-O-methylguanosine
  • HY-154448
    3,5-Bis-O-(2,4-dichlorobenzyl)guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    3,5-Bis-O-(2,4-dichlorobenzyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    3,5-Bis-O-(2,4-dichlorobenzyl)guanosine
  • HY-152797
    N4-Desmethyl-N5-Methyl wyosine

    		Nucleoside Antimetabolite/Analog Others
    N4-Desmethyl-N5-Methyl wyosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N4-Desmethyl-N5-Methyl wyosine
  • HY-152545
    N1,N2-Dimethyl-2’-O-methylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N1,N2-Dimethyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N1,N2-Dimethyl-2’-O-methylguanosine
  • HY-154606
    2'-F-2'-ara-N2-ibu-dG Phosphoramidite

    		Nucleoside Antimetabolite/Analog Cancer
    2'-F-2'-ara-N2-ibu-dG Phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    2'-F-2'-ara-N2-ibu-dG Phosphoramidite
  • HY-154350
    5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine
  • HY-W073825
    N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine
  • HY-154507
    N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine
  • HY-154548
    N2-iso-Butyroyl-5’-O-DMT-3’-O-(methoxyethyl)guanosine

    		Nucleoside Antimetabolite/Analog Others
    N2-iso-Butyroyl-5’-O-DMT-3’-O-(methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-iso-Butyroyl-5’-O-DMT-3’-O-(methoxyethyl)guanosine
  • HY-152547
    N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine
  • HY-154483
    N2-iso-Butyroyl-5’-O-(4,4’-dimethoxytrityl)-3’-O-methylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-iso-Butyroyl-5’-O-(4,4’-dimethoxytrityl)-3’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-iso-Butyroyl-5’-O-(4,4’-dimethoxytrityl)-3’-O-methylguanosine
  • HY-154351
    N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite

    		Nucleoside Antimetabolite/Analog Cancer
    N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite
  • HY-154464
    N2-iso-Butyroyl-5'-O-DMT-3'-deoxy-3'-fluoroguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-iso-Butyroyl-5'-O-DMT-3'-deoxy-3'-fluoroguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-iso-Butyroyl-5'-O-DMT-3'-deoxy-3'-fluoroguanosine
  • HY-152478
    3’-β-C-Ethynylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    3’-β-C-Ethynylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . 3’-β-C-Ethynylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    3’-β-C-Ethynylguanosine
  • HY-154361
    TLR7 agonist 13

    		Nucleoside Antimetabolite/Analog Cancer
    TLR7 agonist 13 is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . TLR7 agonist 13 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    TLR7 agonist 13
  • HY-154349
    N2-iso-Butyroyl-2’-O-propargylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-iso-Butyroyl-2’-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . N2-iso-Butyroyl-2’-O-propargylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N2-iso-Butyroyl-2’-O-propargylguanosine
  • HY-152684
    2′-O-2-Propyn-1-ylguanosine

    		Nucleoside Antimetabolite/Analog Others
    2′-O-2-Propyn-1-ylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . 2′-O-2-Propyn-1-ylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    2′-O-2-Propyn-1-ylguanosine
  • HY-112951
    ChX710
    2 Publications Verification

    		 STING Cancer
    ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3.
    ChX710
  • HY-W015346
    Desaminotyrosine

    3-(4-Hydroxyphenyl)propionic acid

    		 Influenza Virus Endogenous Metabolite Infection
    Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.
    Desaminotyrosine
  • HY-12512
    cGAMP
    5+ Cited Publications

    Cyclic GMP-AMP; 3',3'-cGAMP

    		 STING Inflammation/Immunology
    cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .
    cGAMP
  • HY-110385
    cGAMP disodium
    5+ Cited Publications

    Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium

    		 STING Endogenous Metabolite Inflammation/Immunology
    cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .
    cGAMP disodium
  • HY-110385A
    cGAMP diammonium
    5+ Cited Publications

    Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium

    		 STING Endogenous Metabolite Inflammation/Immunology
    cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .
    cGAMP diammonium
  • HY-P99478
    Bifarcept

    		IFNAR Inflammation/Immunology
    Bifarcept is a recombinant antibody of interferon receptor type I (IFN-RI). Bifarcept can bind IFN-β and prolong its serum half-life .
    Bifarcept
  • HY-143321
    STING agonist-13

    		STING Cancer
    STING agonist-13 is a stimulator of interferon genes (STING) agonist, for cancer immunity via STING-mediated immune activation. STING agonist-13 can stimulate STING downstream signaling and promoting type I interferon immune responses. STING agonist-13 significantly decreases tumor volume and shows immunological memory-derived cancer inhibition .
    STING agonist-13
  • HY-148029
    Dazostinag disodium

    TAK-676

    		 STING Cancer
    Dazostinag disodium (TAK-676) is an agonist of STING, triggering the activation of STING signaling pathway and type I interferons. Dazostinag disodium is also a modulator of immune system, resulting complete regressions and durable memory T-cell immunity. Dazostinag disodium promotes durable IFN-dependent antitumor immunity .
    Dazostinag disodium
  • HY-117066
    CL075
    2 Publications Verification

    3M002

    		 Toll-like Receptor (TLR) Inflammation/Immunology
    CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively .
    CL075
  • HY-10964
    Vadimezan
    Maximum Cited Publications
    34 Publications Verification

    DMXAA; ASA-404

    		 STING IFNAR Influenza Virus Infection Cancer
    Vadimezan (DMXAA; ASA-404), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan has anti-influenza virus H1N1-PR8 activities.
    Vadimezan
  • HY-152955
    STING agonist-22

    		STING Infection Inflammation/Immunology
    STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research .
    STING agonist-22
  • HY-155457
    Enpp-1-IN-19

    		Phosphodiesterase (PDE) STING Cancer
    Enpp-1-IN-19 (compound 29f) is an orally active ENPP1 inhibitor that inhibits cGAMP hydrolysis by ENPP1 (IC50=68 nM). Enpp-1-IN-19 increases anti-PD-L1 responses and inhibits tumor growth in CT26 syngeneic models. Enpp-1-IN-19 also enhances STING-mediated type I interferon responses, induces immune memory, and prevents tumor recurrence .
    Enpp-1-IN-19

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